LETTER

Influence of clinical factors, drug use, and food intake on the glutathione system

H Shirin¹, J T Pinto² and S F Moss³

¹ Tel Aviv University/Edith Wolfson Medical Center, Holon, Israel
² American Health Foundation, Valhalla, NY, USA
³ Brown University/Rhode Island Hospital, Providence, RI, USA

Correspondence to:
Correspondence to:
S F Moss, Rhode Island Hospital, 593 Eddy St, APC 445, Providence, RI 02903, USA;
Steven_Moss_MD@Brown.edu

Keywords: glutathione; glutathione S-transferase; Helicobacter pylori

The first 150 words of the full text of this article appear below.

In a previous issue of Gut, Hoensch and colleagues (Gut 2002;50:235–40) using antral and duodenal biopsies, reported on a variety of factors such as sex, age, drug use, and food intake that influence the concentration of glutathione and the activity of glutathione S-transferase. All of these factors either singly or in combination significantly affect glutathione metabolism within the gastric mucosa.

Curiously, one critical factor that may have influenced their measurements, namely Helicobacter pylori infection, was not mentioned in their paper. This omission is particularly important as the majority of the patients that these investigators examined had endoscopic findings strongly suggestive of infection with H pylori (gastric erythema, erosions, or ulcers). Previous studies by some of the coauthors in the Hoensch paper^1,2 as well as by our group³ have clearly demonstrated that H pylori infection is associated with marked depletion by approximately 50% . . . [Full text of this article]

H Hoensch⁴ and I Morgenstern⁴

⁴ Leitender Arzt, Innere Abteilung, Gastroenterologie und Onkologie, Kreiskrankenhaus Groß-Gerau, Wilhelm Seipp-Staße 3, 64521 Groß-Gerau, Deutchland

Correspondence to:
Correspondence to:
H Hoensch;
H.P.Hoensch@vff.uni-frankfurt.de

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