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Gut 2003;52:1391-1392
© 2003 by BMJ Publishing Group Ltd & British Society of Gastroenterology


COMMENTARY

Colon

Nutritional therapy for cancer cachexia

R F Grimble

Correspondence to:
Correspondence to:
Professor R F Grimble, Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton SO16 7PX, UK;
rfg1@soton.ac.uk


In cancers where high inflammatory stress is usual, protein rich supplements containing n-3 polyunsaturated fatty acids and high levels of antioxidant vitamins can reverse severe weight loss

Keywords: cachexia; pancreatic cancer; quality of life; eicosapentaenoic acid; n-3 fatty acids; nutritional support; weight; lean body mass; cytokines; proteolysis inducing factor

The first 150 words of the full text of this article appear below.

The process of inflammation has a paradoxical effect. This is mostly due to the metabolic responses triggered by the release of the three proinflammatory cytokines, interleukin 1ß (IL-1ß), tumour necrosis factor {alpha} (TNF-{alpha}), and interleukin 6 (IL-6). As an integral part of the body’s response to infection and injury, these mediators release substrate, from host tissues, to support T and B lymphocyte activity, create a hostile environment for invading pathogens, via a raised body temperature and oxidant production, and initiate downregulation of the process once invasion has been defeated.1 All of these metabolic effects come at considerable cost to the host, as witnessed by the extensive tissue depletion, anorexia, and anaemia seen in severely infected and injured patients.2 However, the cost is of great biological value if recovery from infection and injury are achieved. The inflammatory process contains elements which inherently upregulate the response. Oxidants will increase proinflammatory cytokine . . . [Full text of this article]


Relevant Article

Effect of a protein and energy dense n-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial
K C H Fearon, M F von Meyenfeldt, A G W Moses, R van Geenen, A Roy, D J Gouma, A Giacosa, A Van Gossum, J Bauer, M D Barber, N K Aaronson, A C Voss, and M J Tisdale
Gut 2003 52: 1479-1486. [Abstract] [Full Text] [PDF]



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Palliative Medicine, September 1, 2005; 19(6): 500 - 502.
[PDF]




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