COMMENTARY

Inflammatory bowel disease

NOD2/CARD15 and the Paneth cell: another piece in the genetic jigsaw of inflammatory bowel disease

M C Aldhous, E R Nimmo, J Satsangi

Edinburgh University Medical School, Gastrointestinal Unit, Western General Hospital, Edinburgh, UK

Correspondence to:
Correspondence to:
Professor J Satsangi
Edinburgh University Medical School, Gastrointestinal Unit, Western General Hospital, Edinburgh, EH4 2XU, UK; j.satsangi@ed.ac.uk

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Expression of NOD2/CARD15 in the Paneth cell may be critical in the pathogenesis of Crohn’s disease

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Keywords: Crohn’s disease; innate immunity; NOD2/CARD15; Paneth cells

The first 150 words of the full text of this article appear below.

The emergence and application of novel molecular techniques over the last decade has provided a needed catalyst to studies of the pathogenesis of the chronic inflammatory bowel diseases (IBD): Crohn’s disease (CD) and ulcerative colitis (UC). Successful development of genetically engineered models of intestinal inflammation has not only provided insight into the dysregulation of the mucosal immune system characteristic of IBD but has also emphasised the critical and complex role of the bacterial flora in establishing and maintaining chronic intestinal inflammation.¹ These advances in understanding pathophysiology in turn have already led to novel therapeutic approaches.^2,3

However, it is in studies of human genetics that landmark progress has been made, widely recognised not only within gastroenterology but also by investigators in all complex diseases.⁴ Genome wide scanning led initially to the identification of a number of susceptibility loci, the statistical evidence for which satisfy stringent criteria for definite . . . [Full text of this article]

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