© 2003 by BMJ Publishing Group Ltd & British Society of Gastroenterology
Digest
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Little is known about long term risks or benefits of H pylori eradication in asymptomatic people. Ten years ago, the study authors treated a group of completely asymptomatic Italians with H pylori eradication. As the treatment regimens were relatively ineffective, this was only successful in about a half. In this study they have reported what happened to the successfully and unsuccessfully treated groups over eight and a half years. Most remained well, but a few developed symptoms with or without ulcers, and this was more common in the group which remained infected, especially if they were infected with a more pathogenic cag + strain. H pylori eradication has previously been shown to provoke symptoms or endoscopic signs of oesophagitis in some patient groups; that did not occur significantly here although there was a trend towards this and lack of significance may have been due to lack of study power. This
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