© 2003 by BMJ Publishing Group & British Society of Gastroenterology
Digest
Associate Editor
| The first 150 words of the full text of this article appear below. |
The foremost gastroenterologist of his era, William Shakespeare, identified the key functions of the GI tract. In Menenius' brilliant speech in Coriolanus (I,i) he identified the belly as the "storehouse and the shop of the whole body". Shakespeare anticipated early 21st century scientists who have identified the key role of the stomach in human over-nutrition. Ghrelin is fascinating but in this issue Ballinger summarises experiments on the role of GIP (gastric inhibiting polypeptide) in obesity. In mice excess fat intake leads to GIP hypersecretion. Maybe GIP is a potential target for anti-obesity drugs. See 319
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There are few diagnoses in clinical gastroenterology about which clinicians feel less confident than sphincter of Oddi dysfunction. Although manometry is regarded as the most accurate investigation, the procedure is highly invasive and carries real risks. CCK scintigraphy has been has been suggested as a non-invasive alternative. Toouli's
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