© 2003 by BMJ Publishing Group & British Society of Gastroenterology
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Gastric inhibitory polypeptide links overnutrition to obesity
Digestive Disease Research Centre, St Bartholomew’s and the Royal London, Turner Street, London, UK; a.b.ballinger@qmul.ac.uk
A gut derived peptide, gastric inhibitory polypeptide, directly links overnutrition to obesity and may be a potential target for antiobesity drugs
| The first 150 words of the full text of this article appear below. |
Obesity and diabetes are two of the most prevalent health conditions in industrial nations. Recent studies suggest that a gut derived peptide, gastric inhibitory polypeptide (GIP), may be involved in the pathogenesis of type 2 diabetes and obesity induced by overnutrition.1,2 The "thrifty genotype" hypothesis suggests that those who are prone to obesity have been favoured by natural selection in the past because they possess genes that promote the efficient storage of ingested food as body fat for use in periods of undernutrition. However, with the sedentary lifestyle and year round plentiful food supply of modern society, the tendency is to accumulate fat. Miyawaki et al have shown that GIP directly links overnutrition to obesity and may be a potential target for antiobesity drugs.2
GIP was initially discovered and named for its gastric inhibitory properties. In 1886, Ewald and Boas showed that olive oil mixed with a meal inhibited both
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