© 2003 by BMJ Publishing Group & British Society of Gastroenterology
COMMENTARY
Small intestine
Is fracture risk increased in patients with coeliac disease?
Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK
Correspondence to:
Correspondence to:
Box 157, Department of Medicine, Addenbrooke’s Hospital, Cambridge CB2 2QQ, UK;
jec1001@cam.ac.uk
Concerns about fracture risk in patients with coeliac disease may have been exaggerated
Keywords: coeliac disease; osteoporosis; bone fracture
| The first 150 words of the full text of this article appear below. |
Metabolic bone disease is a well established complication of coeliac disease. Early reports focused mainly on the association with vitamin D deficiency and osteomalacia1 but more recently attention has turned to osteoporosis.2 A number of studies have demonstrated reduced bone mineral density in individuals with coeliac disease, particularly in untreated cases and in those who fail to respond fully to a gluten free diet.3 Furthermore, the need to consider coeliac disease as a pathogenetic factor in individuals presenting with osteoporosis has been emphasised; this particularly applies to those with clinical features of the disease and those who fail to respond to treatment for their osteoporosis.
The clinical significance of the observed reduction in bone mineral density associated with coeliac disease is unclear. While a small proportion of patients undoubtedly develop severe osteoporosis with multiple fragility fractures, the question of whether fracture risk is significantly increased across the clinical
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Gut 2003 52: 518-522.[Abstract] [Full Text] [PDF]
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