© 2003 by BMJ Publishing Group & British Society of Gastroenterology
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Reflux is a disease which doctors tend to blame on their patient’s lifestyle. However this month we publish a study which may force a reappraisal of this approach. 4480 pairs of twins from the St Thomas’ Adult UK Twin Registry were sent a questionnaire concerning reflux symptoms. Subjects were considered to be refluxers if they had symptoms at least weekly. Most of the twins are female so their conclusions are strictly only valid for females. By comparing the case wise concordance in monozygotic (46%) and dizygotic twins (26%), the authors were able to estimate the heritability of gastro-oesophageal reflux disease (GORD). After adjusting for body mass index (BMI), the heritability of GORD was estimated to be 43%. The hunt is now on for the genes, which are likely to be multiple.See page 1085
The incidence of adenocarcinoma of the gastric cardia is increasing in developing countries but the pathogenesis
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