COMMENTARY

Inflammatory bowel disease

In vivo electron spin resonance spectroscopy: what use is it to gastroenterologists?

N S Dhanjal¹, I J Cox², S D Taylor-Robinson³

¹ Department of Medicine A, Division of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
² Robert Steiner Magnetic Resonance Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
³ Department of Medicine A, Division of Medicine, and Robert Steiner Magnetic Resonance Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK

Correspondence to:
Correspondence to:
Dr S D Taylor-Robinson, Gastroenterology Unit, Imperial College London, Hammersmith Campus, Du Cane Rd, London W12 0HS, UK;
s.taylor-robinson@imperial.ac.uk

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Electron spin resonance (ESR) spectroscopy may have a role in the future in assessing the mucosal integrity of the colon non-invasively in the otherwise normal looking colon of patients with quiescent colitis

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The first 150 words of the full text of this article appear below.

Like all techniques that strive to bridge the gap between laboratory science and clinical medicine, electron spin resonance (ESR) spectroscopy builds on established applications in biochemistry and chemistry, following on from its discovery by Professor EK Zavoisky and colleagues in 1944 at Kazan State University, situated deep within the Tatarstan Republic of the Russian Federation, formerly the Soviet Union.¹ However, it is only now that developments in technology may perhaps allow the endoscopist of the future to acquire information on gut mucosal integrity in vivo during a procedure. This is an intriguing prospect, although there are a number of practical problems to be solved before the in vivo clinical potential of this sensitive and specific technology is realised. The average endoscopist, faced with the clinical burden of disease and an ever growing case load, requires an emerging clinical technique to robustly deliver reproducible clinically relevant data without . . . [Full text of this article]

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