COMMENTARY

Helicobacter pylori

Helicobacter pylori infection and long term proton pump inhibitor therapy

K E L McColl

Correspondence to:
Correspondence to:
K E L McColl
Section of Medicine, Western Infirmary, 44 Church St, Glasgow G11 6NT, UK; k.e.lmccol@clinmed.gla.ac.uk

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Should Helicobacter pylori infection be eradicated in patients requiring long term proton pump inhibitor therapy for gastro-oesophageal reflux disease?

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Keywords: Helicobacter pylori; gastro-oesophageal reflux disease; gastritis; atrophy; gastric cancer; omeprazole

The first 150 words of the full text of this article appear below.

Should Helicobacter pylori infection be eradicated in patients requiring maintenance proton pump inhibitor therapy for gastro-oesophageal reflux disease? This question has stimulated heated debate and contention over the past few years. The issue first came to prominence in 1996 when Kuipers et al published their study purporting to demonstrate that omeprazole accelerated the development of corpus atrophic gastritis in H pylori infected subjects.¹ This rung alarm bells due to the fact that atrophic gastritis is a well recognised risk factor for gastric cancer in H pylori infected subjects. There was therefore concern that proton pump inhibitor therapy was modifying the inflammatory response to H pylori infection in such a way as to increase the risk of gastric cancer. For this reason, some experts have recommended that H pylori infection should be eradicated prior to long term proton pump inhibitor therapy.²

The original paper by Kuipers et al was . . . [Full text of this article]

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Relevant Article

Cure of Helicobacter pylori infection in patients with reflux oesophagitis treated with long term omeprazole reverses gastritis without exacerbation of reflux disease: results of a randomised controlled trial

E J Kuipers, G F Nelis, E C Klinkenberg-Knol, P Snel, D Goldfain, J J Kolkman, H P M Festen, J Dent, P Zeitoun, N Havu, M Lamm, and A Walan
Gut 2004 53: 12-20. [Abstract] [Full Text] [PDF]

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