COMMENTARY

Cdx genes

The role of Cdx genes in the mammalian gut

F Beck

Correspondence to:
Correspondence to:
Professor F Beck
Department of Biochemistry, University of Leicester, Adrian Building, University Rd, Leicester LE 1 7RH, UK; fb22@le.ac.uk

---

Cdx genes are important in pattern formation during the development of the gut and may well contribute to the balance between differentiation and cell renewal in the mature intestine

---

Keywords: Cdx1; intestinal metaplasia; transgenic mouse stomach; mice

The first 150 words of the full text of this article appear below.

Organisation of multicellular animals involves the action of genes that impart "positional information". All vertebrates are built on a segmental pattern that is most obviously expressed by the appearance of somites during embryonic development.

A common feature of genes that impart individual identity (and therefore positional information) to specific segments is the possession of a "homeobox" DNA binding motif coding for a consensus sequence of 60–63 amino acids that acts as a transcriptional regulator of "downstream" genes. The most widely researched homeobox genes are the so-called homeotic selector genes of the Antp-type (the defining gene is named Antennapaedia). In the fruit fly Drosophila, these are situated on chromosome 3 as part of the HOM cluster. HOM-C genes are strongly conserved during evolution and in mammals have been replicated to appear on separate chromosomes in four paralogous complexes called Hox clusters. They are expressed principally in . . . [Full text of this article]

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Article

Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic mice

H Mutoh, S Sakurai, K Satoh, H Osawa, Y Hakamata, T Takeuchi, and K Sugano
Gut 2004 53: 1416-1423. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

• Fu, Z., Kim, J., Vidrich, A., Sturgill, T. W., Cohn, S. M. (2009). Intestinal cell kinase, a MAP kinase-related kinase, regulates proliferation and G1 cell cycle progression of intestinal epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 297: G632-G640 [Abstract] [Full Text]  
• Baba, Y., Nosho, K., Shima, K., Freed, E., Irahara, N., Philips, J., Meyerhardt, J. A., Hornick, J. L., Shivdasani, R. A., Fuchs, C. S., Ogino, S. (2009). Relationship of CDX2 Loss with Molecular Features and Prognosis in Colorectal Cancer. Clin. Cancer Res. 15: 4665-4673 [Abstract] [Full Text]  
• Park, M. J., Kim, K. H., Kim, H. Y., Kim, K., Cheong, J. (2008). Bile acid induces expression of COX-2 through the homeodomain transcription factor CDX1 and orphan nuclear receptor SHP in human gastric cancer cells. Carcinogenesis 29: 2385-2393 [Abstract] [Full Text]  
• Souza, R. F., Krishnan, K., Spechler, S. J. (2008). Acid, Bile, and CDX: the ABCs of making Barrett's metaplasia. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G211-G218 [Abstract] [Full Text]  
• Cheng, P.-Y., Lin, C.-C., Wu, C.-S., Lu, Y.-F., Lin, C. Y., Chung, C.-C., Chu, C.-Y., Huang, C.-J., Tsai, C.-Y., Korzh, S., Wu, J.-L., Hwang, S.-P. L. (2008). Zebrafish cdx1b regulates expression of downstream factors of Nodal signaling during early endoderm formation. Development 135: 941-952 [Abstract] [Full Text]  
• Ezaki, T., Guo, R.-J., Li, H., Reynolds, A. B., Lynch, J. P. (2007). The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing beta- and p120-catenin tyrosine phosphorylation. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G54-G65 [Abstract] [Full Text]  
• (2007). Abstracts. Gut 56: a1-a145 [Full Text]  
• Calon, A., Gross, I., Davidson, I., Kedinger, M., Duluc, I., Domon-Dell, C., Freund, J.-N. (2007). Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein. Nucleic Acids Res 35: 175-185 [Abstract] [Full Text]  
• Choi, M. Y., Romer, A. I., Hu, M., Lepourcelet, M., Mechoor, A., Yesilaltay, A., Krieger, M., Gray, P. A., Shivdasani, R. A. (2006). A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Development 133: 4119-4129 [Abstract] [Full Text]  
• Ericsson, A., Kotarsky, K., Svensson, M., Sigvardsson, M., Agace, W. (2006). Functional Characterization of the CCL25 Promoter in Small Intestinal Epithelial Cells Suggests a Regulatory Role for Caudal-Related Homeobox (Cdx) Transcription Factors. J. Immunol. 176: 3642-3651 [Abstract] [Full Text]