COMMENTARY

Irritable bowel syndrome

Is there a SERT-ain association with IBS?

M Camilleri

Correspondence to:
Correspondence to:
Professor M Camilleri
CENTER, Mayo Clinic, Charlton 8-110, 200 First St SW, Rochester 55905, USA; camilleri.michael@mayo.edu

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The homozygous short genotype of SERT-P may be a candidate gene for diarrhoea predominant irritable bowel syndrome in women

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Keywords: irritable bowel syndrome; 5-HT; serotonin transporter; polymorphism

The first 150 words of the full text of this article appear below.

In this issue of Gut, Yeo and colleagues¹ report on the association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome (D-IBS) in women (see page 1452). In a study of 194 North American female participants with D-IBS in a clinical trial programme and 448 female controls, there was an association between the homozygous short genotype of SERT-P (serotonin reuptake transporter gene) and the D-IBS phenotype, with an odds ratio of 2.25 (95% confidence interval 1.51–3.31). The fact that the confidence interval does not cross the value of 1 suggests that the association is statistically significant, and the authors suggest that the SERT-P may be a candidate gene for D-IBS in women.

To place these interesting observations in perspective, the reader may wish to address the following. What is SERT? What is the theoretical consequence of a polymorphism . . . [Full text of this article]

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Relevant Article

Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women

A Yeo, P Boyd, S Lumsden, T Saunders, A Handley, M Stubbins, A Knaggs, S Asquith, I Taylor, B Bahari, N Crocker, R Rallan, S Varsani, D Montgomery, D H Alpers, G E Dukes, I Purvis, and G A Hicks
Gut 2004 53: 1452-1458. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

• Jarrett, M. E., Kohen, R., Cain, K. C., Burr, R. L., Poppe, A., Navaja, G. P., Heitkemper, M. M. (2007). Relationship of SERT Polymorphisms to Depressive and Anxiety Symptoms in Irritable Bowel Syndrome. Biol Res Nurs 9: 161-169 [Abstract]