© 2004 by BMJ Publishing Group Ltd & British Society of Gastroenterology
EDITOR'S QUIZ: GI SNAPSHOT
A phenomenal response to treatment by an advanced tumour
St James’s University Hospital, Leeds, UK
Correspondence to:
Correspondence to:
Mr S H Rahman
St James’s University Hospital, Beckett St, Leeds LS2 2LY, UK; zak-rahman@lineone.net
Keywords: gastrointestinal stromal tumour; Glivec; metastases; imatinib mesylate
| The first 100% of the full text of this article appears below. |
A 44 year old woman presented with a longstanding history of epigastric pain, weight loss, and dysphagia. Upper gastrointestinal duodenoscopy demonstrated an 8 cm infiltrating tumour of the proximal (40 cm) stomach, and biopsy of the lesion demonstrated a necrotic solid tumour with a predominant epithelioid morphology arranged in small solid clusters with multiple scattered mitotic figures. Immunohistochemical staining revealed strong expression of vimentin, CD34, and c-kit in virtually all tumour cells. In view of her symptoms and histological findings, a contrast enhanced computed tomography (CT) scan of her abdomen was performed (fig 1
).
[in a new window] Figure 1 Contrast enhanced computed tomography scan of the abdomen (left) and immunohistochemical staining of the biopsy specimen of the lesion (right).
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What do the investigations reveal as the likely diagnosis, and what are the treatment options for this patient?
See page 1616 for answer
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Gut 2004 53: 1616.[Extract] [Full Text] [PDF]
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