© 2004 by BMJ Publishing Group Ltd & British Society of Gastroenterology
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From question on page 161
Although anticoagulation for cerebral sinus thrombosis remains controversial, a recent Cochrane review concluded that anticoagulation was safe and associated with a potentially important reduction in the risk of death or dependency. In this case, following discussion with neurologists, she was anticoagulated for a four month period. Her vision slowly improved but did not return to normal. No prothrombotic state other than her inflammatory bowel disease (IBD) and her being on the pill could be identified. The pill was stopped and she was counselled on different methods of contraception.
In IBD, histological and haematological studies suggest that a hypercoaguable state is involved in the pathogenesis of venous thrombosis. The exact mechanism is unknown but is bound to be multifactorial. During acute flare up there are increases in factor VIII, fibrinogen, platelets, and factor V, and a decrease in antithrombin III, all of which may contribute. Thrombosis
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Gut 2004 53: 161.[Extract] [Full Text] [PDF]
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