COMMENTARY

Familial adenomatous polyposis

Extracolonic polyposis in familial adenomatous polyposis: so near and yet so far

A D Spigelman

Correspondence to:
Correspondence to:
A D Spigelman
Surgical Science, Faculty of Health, University of Newcastle, Director, Hunter Family Cancer Service, Director, Cancer Services and Director, Clinical Governance Unit, Hunter Area Health Service, New South Wales, Australia; allan.spigelman@newcastle.edu.au

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There is a need to develop effective preventative and/or curative strategies for duodenal polyposis in patients with familial adenomatous polyposis

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Keywords: familial adenomatous polyposis; duodenal adenomatosis; duodenal carcinoma

The first 150 words of the full text of this article appear below.

Extracolonic polyps in familial adenomatous polyposis (FAP) were described in the stomach by Hauser in 1895 and in the duodenum by Funkenstein in 1904.¹ These findings postdate the first description of colonic lesions consistent with polyposis, described by Menzel in 1721, although this case is probably a description of inflammatory polyps.¹ The first case of adenomatous polyposis may have been recorded by Corvisart in 1847.¹ However, the first definite accounts of the disease were given by Chargelaigue in 1859 in a 16 year old girl and a 21 year old man.¹ While polyposis has thus been reasonably well described for hundreds of years and the coexistence of extracolonic polyps in this syndrome has been known for over 100 years, it was not until 1987 that the name familial polyposis coli was abandoned in order to reflect the disparate manifestations of this syndrome throughout the body.²

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