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Gut 2004;53:330; doi:10.1136/gut.2003.029876
Copyright © 2004 BMJ Publishing Group Ltd & British Society of Gastroenterology.
Gut 2004;53:330
© 2004 by BMJ Publishing Group Ltd & British Society of Gastroenterology

GI SNAPSHOT

Menetrier disease

A Cardenas, C Kelly

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA

Correspondence to:
Correspondence to:
Dr A Cardenas
Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis St-Suite 8E, Boston, Massachusetts 02215, USA; acardena@bidmc.harvard.edu

Keywords: Menetrier disease; hypertropic gastropathy; foveolar hyperplasia; transforming growth factor {alpha}

The first 100% of the full text of this article appears below.

QUESTION

A 31 year old man presented with nausea, epigastric discomfort, and weakness. He reported coffee ground emesis, melena, and had a history of iron deficiency anaemia of two years requiring oral iron supplementation and repeated blood transfusions. He had no other significant medical, surgical, or family history. Computed tomography scan of the abdomen revealed marked diffuse thickening of the gastric walls without any lymphadenopathy. Upper gastrointestinal endoscopy revealed giant folds with a polypoid appearance in the body and fundus of the stomach (fig 1Go). Mucosal biopsies of the fundus, body, and antrum were obtained. Stains for Helicobacter pylori were negative. The history and histological findings of this case are consistent with what disease?


 

See page 338 for answer


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