COMMENTARY

Cancer

Gene transfer: Bax to the future for cancer therapy

N R Lemoine, I A McNeish

Cancer Research UK Clinical Centre, Sir John Vane Science Building, Barts and the London School of Medicine and Dentistry, London, UK

Correspondence to:
Correspondence to:
Professor N R Lemoine
Cancer Research UK Clinical Centre, Sir John Vane Science Building, Barts and the London School of Medicine and Dentistry, Charterhouse Sq, London EC1M 6BQ, UK; nick.lemoine@cancer.org.uk

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The Bax gene as a competitor in the marathon towards licensed cancer gene therapy

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The first 150 words of the full text of this article appear below.

Intraperitoneal spread of gastrointestinal malignancies is a significant clinical problem and contributes to an incidence of distant relapse as high as 30% in gastric cancer. Local dissemination of tumour cells into the peritoneal cavity determines the outcome in advanced gastric cancer and diffuse-type carcinoma, and patients with negative peritoneal washings have a more favourable prognosis. Extensive lymph node dissection has been shown (by quantitative reverse transcription-polymerase chain reaction for carcinoembryonic antigen and cytokeratin 20 combined with extensive intraoperative peritoneal lavage¹) to open lymphatic channels and spread viable cancer cells into the peritoneal cavity. Hence patient subpopulations that might benefit from intraperitoneal therapy regimens may be identified.

Malignant disease localised within the abdominal cavity has been a target for the staged development of clinical gene therapy approaches because of the smaller doses of experimental agent and increased safety margins over systemic administration. There has been extensive—and safe—experience of p53 . . . [Full text of this article]

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