© 2004 by BMJ Publishing Group Ltd & British Society of Gastroenterology
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While the association of H pylori infection with gastritis, ulcers and cancer have been recognised for many years it is only now that the molecular mechanisms are starting to be understood. Ashktorab and colleagues [see page 805] assessed the effects of H pylori co-incubation on the mitochondria of various cell lines. Within 3 hours the pro-apoptotic protein Bax is translocated to the mitochondria. The mitochondria are depolarised and fragmented within 4 or 5 hours of incubation. By using cells which lack functional p53 they showed that the effect of H pylori was partially mediated through this pathway and could be blocked by the cytoprotective oncoprotein Bcl-2. This opens the way to further work to identify the individual characteristics of host or bacteria which determine whether the end result of this interaction is ulceration or cancer.
See page 805
There is increasing interest in the potential beneficial effects of probiotic
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