COMMENTARY

Leptin

Leptin in intestinal inflammation: good and bad gut feelings

G Matarese¹, R I Lechler²

¹ Gruppo di ImmunoEndocrinologia, Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli "Federico II", Via S Pansini, 5-80131, Napoli, Italy
² Department of Immunology, Imperial College School of Medicine, Hammersmith Campus, London, UK

Correspondence to:
Correspondence to:
Professor R I Lechler
Department of Immunology, Imperial College School of Medicine, Hammersmith Campus, Du Cane Road, London W12 ONN, UK; r.lechler@imperial.ac.uk

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Leptin has a the potent effect on T cell mediated intestinal autoimmunity and may have a role in the development of such diseases

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Keywords: leptin; intestinal inflammation; cytokines; colitis; apoptosis; T lymphocytes

The first 150 words of the full text of this article appear below.

Leptin, a molecule that is critical in the regulation of energy balance, body weight, and reproductive function, is a strong regulator of T cell function.¹ This is one of many examples of redundancy and of the overlapping roles of molecules within the neuroendocrine and immune systems.² Leptin is part of the helical cytokine family along with interleukin (IL-) 6, IL-12, and IL-15, its receptor (ObR) belonging to the group of class I cytokine receptors, which includes gp-130, the common signal transducing component for the IL-6 related family of cytokines.¹ Leptin is expressed particularly in adipose tissue and to a lesser extent in other tissues such as muscle, stomach, and placenta.¹ More recently, leptin has also been shown to be expressed in activated inflammatory T helper 1 lymphocytes during experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.³ In keeping with these findings, the ObR has been found not only . . . [Full text of this article]

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