© 2004 by BMJ Publishing Group Ltd & British Society of Gastroenterology
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| The first 150 words of the full text of this article appear below. |
Helicobacter pylori infection is associated with an acute inflammatory response which involves an up-regulation of interferon (IFN
), tumour necrosis factor (TNF) and interleukin1-ß. The counter regulatory cytokine IL-10 is also increased and the balance of these pro- and anti-inflammatory cytokines influences disease outcome. Functional polymorphisms in the IL-10, IL-1ß, TNF
, IFN and IL-10 have all been reported. The current study aims to assess the overall impact of these polymorphisms on the response to H pylori, which for most patients produces few symptoms and only modest inflammation. Over 200 patients were characterised as regards their genetic polymorphisms and response to H pylori infection. The mucosal production of IL-1ß in response to H pylori infection was shown to be highest in those with the combination of the IL-1ß 511T and the interleukin receptor antagonist IL-RN*2+ polymorphisms. Likewise the high producing IL-10 polymorphism – 1082 GG resulted in a nearly
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