COMMENTARY

Coeliac disease

T helper cell polarisation in coeliac disease: any (T-)bet ?

M H Holtmann and M F Neurath

1st Department of Medicine, Johannes Gutenberg-University, Mainz, Germany

Correspondence to:
Correspondence to:
Dr M F Neurath
Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Langenbeckstrasse 1, Germany; neurath@1-med.klinik.uni-mainz.de

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Recent data strongly support the view that coeliac disease is a Th1 mediated inflammatory disease as both interferon production and T-bet levels in gut infiltrating cells are upregulated

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Keywords: coeliac disease; T-bet; STAT-1

The first 150 words of the full text of this article appear below.

The puzzling observation on high interferon (IFN-) but low interleukin (IL)-12 levels in coeliac disease (CD) has resulted in questions about the underlying principles of T helper cell polarisation. In this issue of Gut,¹ the molecular basis of T helper cell polarisation in CD has been illuminated by the finding that T-bet, the master transcription factor of T helper cell type 1 (Th1) cells, is upregulated in this disease [see page 1090].

The past decade has witnessed a dramatic improvement in our pathophysiological understanding of inflammatory disorders of the intestinum due to extensive research efforts focusing on regulatory mechanisms of the immune system. This has been greatly facilitated by the advent of molecular biological techniques which have allowed for the identification and characterisation of distinct factors in the complex regulatory network of the immune system. General themes have thus been recognised and an . . . [Full text of this article]

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Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa

I Monteleone, G Monteleone, G Del Vecchio Blanco, P Vavassori, S Cucchiara, T T MacDonald, and F Pallone
Gut 2004 53: 1090-1095. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

• Li, B, Yang, P, Zhou, H, Huang, X, Jin, H, Chu, L, Gao, Y, Zhu, L, Kijlstra, A (2005). Upregulation of T-bet expression in peripheral blood mononuclear cells during Vogt-Koyanagi-Harada disease. Br. J. Ophthalmol. 89: 1410-1412 [Abstract] [Full Text]