© 2004 by BMJ Publishing Group Ltd & British Society of Gastroenterology
Digest
| The first 150 words of the full text of this article appear below. |
Most gastro-oesophageal reflux events occur because of transient lower esophageal sphincter relaxations (TLESRs). The present treatment of this ubiquitous problem leaves these TLESRs unaltered and replaces the abnormality of reflux with another, namely achlorhydria. Opiates reduce TLESRs but until now the mechanism was unknown. Penagini and colleagues studied the lower oesophageal sphincter of healthy volunteers whose stomachs were distended with a barostat balloon. When the distension was held at a constant pressure, morphine decreased the size of the stomach and the incidence of TLESRs. However, when the distension was at a constant volume, no such effect was seen. Thus, the authors conclude that morphine acts by reducing the gastric volume and suggest that this approach might lead to the development of more specific treatment for reflux.
See page 1227
For most endoscopists the larynx is something one tries to avoid on the way to the stomach, but the evidence in
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Articles
- Relationship between motor function of the proximal stomach and transient lower oesophageal sphincter relaxation after morphine
- R Penagini, M Allocca, P Cantù, M Mangano, D Savojardo, S Carmagnola, and P A Bianchi
Gut 2004 53: 1227-1231.[Abstract] [Full Text] [PDF]
- Controlled prospective evaluation of the diagnostic yield of a laryngopharyngeal screening examination during upper gastrointestinal endoscopy
- B Mullhaupt, D Jenny, S Albert, S Schmid, and M Fried
Gut 2004 53: 1232-1234.[Abstract] [Full Text] [PDF]
-
Downregulation of epithelial apoptosis and barrier repair in active Crohn’s disease by tumour necrosis factor
antibody treatment
- S Zeissig, C Bojarski, N Buergel, J Mankertz, M Zeitz, M Fromm, and J D Schulzke
Gut 2004 53: 1295-1302.[Abstract] [Full Text] [PDF]
- Divergent patterns of total and cancer mortality in ulcerative colitis and Crohn’s disease patients: the Florence IBD study 1978–2001
- G Masala, S Bagnoli, M Ceroti, C Saieva, G Trallori, I Zanna, G d’Albasio, and D Palli
Gut 2004 53: 1309-1313.[Abstract] [Full Text] [PDF]
- Sustained virological response in hepatitis C virus type 1b infected patients is predicted by the number of mutations within the NS5A-ISDR: a meta-analysis focused on geographical differences
- M Pascu, P Martus, M Höhne, B Wiedenmann, U Hopf, E Schreier, and T Berg
Gut 2004 53: 1345-1351.[Abstract] [Full Text] [PDF]
This article has been cited by other articles:
-
Rubio, C A, Nesi, G, Zampi, G C, de Ruiz, P A, Jessurun, J, Jonasson, J, Hojman, R, Kogan, Z, Antonioli, D, Miller, M L, Hirota, T, Itabashi, T, Mandai, K, Kitagawa, T, Sugano, H, Kato, Y, King, A, Pisano, R, Owen, D
(2005). Gastric ciliated metaplasia. A study of 3406 gastrectomy specimens from dwellers of the Atlantic and the Pacific basins. J. Clin. Pathol.
58: 605-610
[Abstract] [Full Text]
Services
- Email this link to a friend
- Similar articles in this journal
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
