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Use of cyclosporin in pregnancy

¹ Department of Gastroenterology, Epsom General Hospital, Epsom, Surrey, UK
² Department of Obstetric Medicine, Epsom General Hospital, Epsom, Surrey, UK

Correspondence to:
Correspondence to:
Dr A Jayaprakash
130 Farriers Road, Epsom KT17 1NS, UK; jaypy@hotmail.com

Keywords: cyclosporin; pregnancy; ulcerative colitis

The first 150 words of the full text of this article appear below.

Cyclosporin has been established in the management of steroid resistant severe ulcerative colitis. We read the letter by Dor and Blanshard (Gut 2003;52:1070-a) regarding the severe side effects of cyclosporin used in a patient with steroid resistant severe ulcerative colitis after undergoing emergency Caesarean section. We would like to report our experience of a pregnant patient with steroid resistant severe distal ulcerative colitis in whom remission was induced with cyclosporin. She delivered a healthy baby at 34 weeks.

A 36 year old woman presented for the first time with a five week history of bloody diarrhoea and mucus discharge in the 12th week of her first pregnancy. Ulcerative colitis was confirmed on flexible sigmoidoscopy and histology. She was started on mesalazine (Pentasa) 1 g twice daily orally and Pentasa enema was added subsequently. She failed to respond well to oral prednisolone (40–60 mg daily) for five weeks . . . [Full text of this article]

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