© 2004 by BMJ Publishing Group Ltd & British Society of Gastroenterology
FOREWORD
Visceral afferent mechanisms and their implications for functional disorders of the gastrointestinal tract
| The first 150 words of the full text of this article appear below. |
Until now, the development of effective therapies for the treatment of functional disorders such as irritable bowel syndrome (IBS) has been thwarted by a general lack of knowledge about how events in the intestine are detected by visceral afferent neurones.
There are considerable gaps in our knowledge of the anatomy as well as the function and modulation of visceral afferent projections, in particular about what causes visceral hypersensitivity or abnormal sensory perception of stimuli in the gut. The field is advancing rapidly and it is rare that bench researchers and clinicians come together to compare and discuss the implications of their results. This supplement consists of a series of specialised papers by some of the best experts in this field, arising from a workshop that took place in 2002 under the auspices of AstraZeneca. The workshop was aimed at reviewing the current status of knowledge relating to the way in
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