Digest
| The first 150 words of the full text of this article appear below. |
Delayed gastric emptying, often associated with evidence of autonomic neuropathy, can be an important problem in diabetes. Numerous treatments have been suggested but none are particularly effective. Ghrelin is a regulatory peptide produced by the enteroendocrine cells of the stomach. Ghrelin blood levels rise before eating and are known to stimulate migrating motor complexes, enhance appetite, and increase food intake in man. Decreased levels following gastrectomy may be responsible for fat depletion and anorexia. The authors of the present study infused ghrelin at a dose known to stimulate appetite. They showed accelerated gastric emptying as assessed by ultrasound. Ghrelin is likely to act on the vagus and myenteric plexus, which both express the growth hormone secretory receptor for which ghrelin is a ligand. The search is now on for orally active analogues of ghrelin, which could prove to be a novel class of prokinetics.
See p 1693
Previous studies have
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Articles
- Tumour matrilysin expression predicts metastatic potential of stage I (pT1) colon and rectal cancers
- S Kurokawa, Y Arimura, H Yamamoto, Y Adachi, T Endo, T Sato, T Suga, M Hosokawa, Y Shinomura, and K Imai
Gut 2005 54: 1751-1758.[Abstract] [Full Text] [PDF]
- Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study
- C D R Murray, N M Martin, M Patterson, S A Taylor, M A Ghatei, M A Kamm, C Johnston, S R Bloom, and A V Emmanuel
Gut 2005 54: 1693-1698.[Abstract] [Full Text] [PDF]
- Diagnosis of small bowel Crohn’s disease: a prospective comparison of capsule endoscopy with magnetic resonance imaging and fluoroscopic enteroclysis
- J G Albert, F Martiny, A Krummenerl, K Stock, J Leßke, C M Göbel, E Lotterer, H H Nietsch, C Behrmann, and W E Fleig
Gut 2005 54: 1721-1727.[Abstract] [Full Text] [PDF]
- A randomised controlled trial assessing the efficacy and safety of repeated tegaserod therapy in women with irritable bowel syndrome with constipation
- J Tack, S Müller-Lissner, P Bytzer, R Corinaldesi, L Chang, A Viegas, S Schnekenbuehl, C Dunger-Baldauf, and P Rueegg
Gut 2005 54: 1707-1713.[Abstract] [Full Text] [PDF]
Services
- Email this link to a friend
- Similar articles in this journal
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
