© 2005 by BMJ Publishing Group Ltd & British Society of Gastroenterology
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The late presentation and frequent chemotherapy resistance of gastric cancer makes this study of great interest. The authors used an elegant gene therapy approach targeting the insulin-like growth factor receptor (IGF-1r). They used an adenovirus vector to insert two types of defective receptors, which interfere with the function of the normal receptor, the so called "dominant negative" IGF receptors. The adenovirus treated cells failed to grow in response to IGF and also showed defective growth and enhanced apoptosis in response to alcohol, 5FU, and irradiation. Not only did the transduced cells fail to grow when implanted in vivo, but the adenovirus treatment also reduce the growth of established peritoneal metastases. This elegant work, which takes us from basic cell biology to cancer chemotherapy, offers new hope for the future treatment of this dreadful disease.
See p 591
Evidence from a range of murine models clearly show that chronic inflammation in
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