© 2005 by BMJ Publishing Group Ltd & British Society of Gastroenterology
COMMENTARY
Haematopoietic cancer
Clinical epidemiology—how important now?
Correspondence to:
Correspondence to:
Dr V Binder
Herlev Hospital, DK 2730 Herlev, Copenhagen, Denmark; vibeke@binders.dk
The putative risk of haematopoietic cancer in relation to modern strong immunosuppressive treatment in inflammatory bowel disease
Keywords: haematopoietic cancer; inflammatory bowel disease; Sweden; leukaemia; lymphoma; epidemiology
| The first 150 words of the full text of this article appear below. |
Chronic diseases have become an increasing portion of modern medicine in the Western world and the goals for treatment are not only to relieve symptoms and their influence on daily life for patients but also to avoid long term complications of the disease and of the treatment given.
The rules for obtaining evidence of the benefit of a new treatment have been widely accepted, with the randomised controlled study as the "gold standard". Such studies give some guarantee of the effect of a given treatment modality. The possible long term side effects however cannot be secured against in studies carried out over a few months, the usual length of a controlled trial.
The natural history of a chronic disease—how will the disease proceed if no medical intervention is carried out—should ideally be the background for any therapeutic trial. For the immediate short term course, the placebo arm of
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Gut 2005 54: 617-622.[Abstract] [Full Text] [PDF]
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