© 2005 by BMJ Publishing Group Ltd & British Society of Gastroenterology
COMMENTARY
GORD
Gastro-oesophageal reflux disease: symptoms, erosions, and Barrett’s—what is the interplay?
Correspondence to:
Correspondence to:
Professor P Sharma
University of Kansas School of Medicine, VA Medical Center, Kansas City, MO 64128, USA; psharma@kumc.edu
The presence of Barrett’s oesophagus may exert a negative impact on healing of erosive oesophagitis in gastro-oesophageal reflux disease
Keywords: Barrett’s oesophagus; Helicobacter pylori; gastro-oesophageal reflux disease; erosive reflux disease; non-erosive reflux disease; heartburn oesophagitis; esomeprazole
| The first 150 words of the full text of this article appear below. |
The outcomes of patients with erosive oesophagitis, treated with acid suppression therapy (proton pump inhibitors), has been dictated by the baseline severity of erosive oesophagitis, presence of hiatus hernia, duration of therapy and, in some studies, by the Helicobacter pylori status of the patients.1,2 It has been shown that higher grades of erosive oesophagitis (Los Angeles grades C and D) have significantly lower healing rates as opposed to those with lower grades of erosive oesophagitis (grades A and B). Moreover, the majority of the oesophagitis trials have evaluated healing at four and eight weeks, showing a higher proportion of patients with all grades of erosive oesophagitis healed at week 8 compared with week 4.3,4 Similar data on healing at >8 weeks are not consistently available in the literature. Not only do patients with severe grades of erosive oesophagitis have a higher degree of oesophageal acid exposure compared with those
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Gut 2005 54: 746-751.[Abstract] [Full Text] [PDF]
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