© 2005 by BMJ Publishing Group Ltd & British Society of Gastroenterology
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D. A. van Heel1, S. Ghosh1, M. Butler1, K. A. Hunt1, A. Lundberg1, T. Ahmad2, D. P. B. McGovern2, C. Onnie3, K. Negoro2, S. Goldthorpe2, B. M. J. Foxwell1, C. G. Mathew3, A. Forbes1, D. P. Jewell2, R. J. Playford1.1Imperial College; 2University of Oxford; 3GKT School of Medicine
Introduction and Aims: Both NOD2/CARD15 alleles are mutated in about 15% of Crohn’s disease patients, but functional effects remain unclear. Most studies have been performed in transfected cell lines, which may not reflect function in primary human cells, particularly interactions with toll-like receptor (TLR) pathogen recognition pathways.
Methods: Peripheral blood mononuclear cells (PBMC) were cryopreserved from wild type controls (n = 7), NOD2 1007fs/1007fs (n = 4), 908Arg/1007fs (n = 4), 702Trp/1007fs (n = 6), 702Trp/702Trp (n = 5). Cells were stimulated for 22 hours with
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Gut 2006 55: a1-a119.[Extract] [Full Text] [PDF]
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