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Guidelines for the management of patients with pancreatic cancer periampullary and ampullary carcinomas

Correspondence to:
Correspondence to:
MrC D Johnson
University Surgical Unit, Mail point 816, Southampton General Hospital, Southampton SO16 6YD, UK; c.d.johnson@soton.ac.uk

Abbreviations: CT, computed tomography; MR, magnetic resonance; MRCP, magnetic resonance cholangiopancreatography; ERCP, endoscopic retrograde cholangiopancreatography; MRA, magnetic resonance angiography; FAP, familial adenomatous polyposis; EUS, endosonography; 5-FU, 5-fluorouracil

Keywords: guidelines; pancreatic cancer; periampullary carcinoma; ampullary carcinoma

The first 150 words of the full text of this article appear below.

	1.0 GUIDELINES—SUMMARY DOCUMENT

 
The following recommendations are introduced by brief statements which summarise the evidence and discussion presented in the relevant section of the full text of the guidelines.

1.1 Incidence, mortality rates, and aetiology
Pancreatic cancer is an important health problem for which no simple screening test is available. The strongest aetiological association is with cigarette smoking, although at risk groups include patients with chronic pancreatitis, adult onset diabetes of less than two years’ duration, hereditary pancreatitis, familial pancreatic cancers, and certain familial cancer syndromes. Periampullary cancers are a feature of familial adenomatous polyposis.

Recommendations Continued health education to reduce tobacco consumption should lower the risk of developing pancreatic carcinoma (grade B). All patients at increased inherited risk of pancreatic cancer should be referred to a specialist centre offering specialist clinical advice and genetic counselling and appropriate genetic testing (grade B). Secondary screening for pancreatic cancer in high risk cases should be carried out as part of an . . . [Full text of this article]

 

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				P. Ghaneh, E. Costello, and J. P Neoptolemos Biology and management of pancreatic cancer Gut, August 1, 2007; 56(8): 1134 - 1152. [Full Text] [PDF]