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Gut 2006;55:1
Copyright © 2006 BMJ Publishing Group Ltd & British Society of Gastroenterology.

Digest

Robin Spiller, Alistair Watson, Editor and Deputy Editor

The first 150 words of the full text of this article appear below.

BILE SALTS IN GASTRO-OESOPHAGEAL REFLUXATE STIMULATES EXPRESSION OF CDX2 WHICH CHANGES SQUAMOUS EPITHELIUM INTO INTESTINAL COLUMNAR EPITHELIUM


Barrett’s oesophagus is a condition in which the squamous epithelium of distal oesophagus is replaced by columnar epithelium more characteristic of the intestine. This phenomenon dramatically increases the risk of adenocarcinomas of the oesophagus and is largely caused by gastro-oesophageal reflux. Some investigators have noticed this change is reminiscent of the development of the gut in the embryo. Factors in the mesoderm cause the endoderm to differentiate into midgut and hindgut. The precursor of the stomach is seen as the "default" phenotype which must be actively converted to midgut or intestinal phenotype. Cdx2 is a transcription factor that causes activates a family of genes causing the stomach precursor to change into the intestine. It is therefore an interesting hypothesis that Cdx2 might be responsible for the conversion of squamous epithelium to columnar epithelium of the intestine. In this article the authors demonstrate that expression of Cdx2 is stimulated by cholic . . . [Full text of this article]


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