COMMENTARY
Oesophagus
Impedance-pH monitoring in proton pump inhibitor resistant patients: ready for clinical application?
Correspondence to:
Correspondence to:
Professor J P Galmiche
Institut des Maladies de l’Appareil Digestif, University Hospital Hôtel-Dieu, 44093 Nantes, France; jeanpaul.galmiche@chu-nantes.fr
Impedance-pH monitoring represents a useful tool for studies and clinical research in oesophageal disorders, and may hold promise for the group of patients dissatisfied with their antireflux treatment
Keywords: multichannel intraluminal impedance and pH; gastro-oesophageal reflux disease; non-acid reflux; proton pump inhibitor; symptom analysis
| The first 150 words of the full text of this article appear below. |
Gastro-oesophageal reflux disease (GORD) is a very common disorder in which the reflux of gastric (or gastroduodenal) contents causes troublesome symptoms and/or lesions of the oesophageal mucosa. The harmful effects of acid injury on the oesophageal mucosa have been established for decades by experimental and clinical studies.1 From a clinical and therapeutic viewpoint, the central role of acid in the pathogenesis of reflux symptoms and lesions of the oesophagitis was most convincingly confirmed by the introduction of acid suppressive therapy; the development of proton pump inhibitors (PPIs) achieved a level of efficacy not previously reached by antacids or H2 blockers.2
Despite the progress made with PPIs, it has now however become clear that up to 40% of patients with GORD symptoms are either not completely satisfied with their acid suppressive therapy or may be resistant to PPIs.3 Several reasons may underlie an individual’s resistance to his or her PPI
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Article
- Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring
- I Mainie, R Tutuian, S Shay, M Vela, X Zhang, D Sifrim, and D O Castell
Gut 2006 55: 1398-1402.[Abstract] [Full Text] [PDF]
- Full Text
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
