COMMENTARY
Oesophagus
Impedance-pH monitoring in proton pump inhibitor resistant patients: ready for clinical application?
Correspondence to:
Correspondence to:
Professor J P Galmiche
Institut des Maladies de lAppareil Digestif, University Hospital Hôtel-Dieu, 44093 Nantes, France; jeanpaul.galmiche@chu-nantes.fr
Impedance-pH monitoring represents a useful tool for studies and clinical research in oesophageal disorders, and may hold promise for the group of patients dissatisfied with their antireflux treatment
Keywords: multichannel intraluminal impedance and pH; gastro-oesophageal reflux disease; non-acid reflux; proton pump inhibitor; symptom analysis
| The first 150 words of the full text of this article appear below. |
Gastro-oesophageal reflux disease (GORD) is a very common disorder in which the reflux of gastric (or gastroduodenal) contents causes troublesome symptoms and/or lesions of the oesophageal mucosa. The harmful effects of acid injury on the oesophageal mucosa have been established for decades by experimental and clinical studies.1 From a clinical and therapeutic viewpoint, the central role of acid in the pathogenesis of reflux symptoms and lesions of the oesophagitis was most convincingly confirmed by the introduction of acid suppressive therapy; the development of proton pump inhibitors (PPIs) achieved a level of efficacy not previously reached by antacids or H2 blockers.2
Despite the progress made with PPIs, it has now however become clear that up to 40% of patients with GORD symptoms are either not completely satisfied with their acid suppressive therapy or may be resistant to PPIs.3 Several reasons may underlie an individuals resistance to his or her PPI
Relevant Article
- Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring
- I Mainie, R Tutuian, S Shay, M Vela, X Zhang, D Sifrim, and D O Castell
Gut 2006 55: 1398-1402.[Abstract] [Full Text] [PDF]
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