EDITOR'S QUIZ: GI SNAPSHOT
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From question on page 1402
Figure 2 shows columnar epithelium (arrow) which is of the non-mucin secreting type, and in fig 3 the surrounding stroma is positive for CD10 (positivity being reflected by the areas of brown staining) consistent with the diagnosis of colonic endometriosis. CD10, a human membrane associated neutral endopeptidase, is widely used in lymphoma phenotyping but it also stains normal, ectopic, and neoplastic endometrial stromal cells. Hence it is used as an adjunctive diagnostic tool in difficult cases of endometriosis.
Endometriosis is a common condition affecting 8–15% of menstruating women. Colonic involvement is seen in 15–37% of patients with pelvic endometriosis. Meyer described the first case of colonic endometriosis in 1909 and Bashist et al reported the first colonic endometriosis confirmed on endoscopic biopsy in 1983.
The intestinal tract is the most common site for extra-genital endometriosis. Other sites include the urinary tract, surgical scars, skin, umbilicus,
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Gut 2006 55: 1402.[Extract] [Full Text] [PDF]
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