RECENT ADVANCES IN CLINICAL PRACTICE

Alterations in intestinal permeability

M C Arrieta, L Bistritz, J B Meddings

Department of Medicine, University of Alberta, Alberta Canada

Correspondence to:
Correspondence to:
Dr J B Meddings
Department of Medicine, 2F1.30 Walter C Mackenzie, Health Sciences Center, 8440-112 St, Edmonton, Alberta Canada; jon.meddings@ualberta.ca

Keywords: intestinal permeability; inflammatory bowel disease; coeliac disease; diabetes

The first 150 words of the full text of this article appear below.

The goal of this review is to describe barrier function of the intestine, the structure of the tight junction, methods to evaluate intestinal permeability, and most importantly the relevance of abnormal permeability to disease. In this context, we will also present an emerging paradigm regarding the genesis of autoimmune diseases and describe the data that supports this from the perspective of both human disease and animal models. While this is a complicated area there are several points worth remembering:

• epithelial permeability of the gastrointestinal tract can be evaluated in a site specific manner;
  
• increased intestinal permeability is observed in association with several autoimmune diseases. It is observed prior to disease and appears to be involved in disease pathogenesis;
  
• there are new and novel therapies directed at altering abnormally increased intestinal permeability and these may play a role in treating or preventing these diseases.
  

From the lower oesophageal sphincter to the . . . [Full text of this article]

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Tripathi, A., Lammers, K. M., Goldblum, S., Shea-Donohue, T., Netzel-Arnett, S., Buzza, M. S., Antalis, T. M., Vogel, S. N., Zhao, A., Yang, S., Arrietta, M.-C., Meddings, J. B., Fasano, A. (2009). Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc. Natl. Acad. Sci. USA 106: 16799-16804 [Abstract] [Full Text]  
• Sokol, H, Polin, V, Lavergne-Slove, A, Panis, Y, Treton, X, Dray, X, Bouhnik, Y, Valleur, P, Marteau, P (2009). Plexitis as a predictive factor of early postoperative clinical recurrence in Crohn's disease. Gut 58: 1218-1225 [Abstract] [Full Text]  
• Muise, A M, Walters, T D, Glowacka, W K, Griffiths, A M, Ngan, B-Y, Lan, H, Xu, W, Silverberg, M S, Rotin, D (2009). Polymorphisms in E-cadherin (CDH1) result in a mis-localised cytoplasmic protein that is associated with Crohn's disease. Gut 58: 1121-1127 [Abstract] [Full Text]  
• Schepens, M. A. A., Schonewille, A. J., Vink, C., van Schothorst, E. M., Kramer, E., Hendriks, T., Brummer, R.-J., Keijer, J., van der Meer, R., Bovee-Oudenhoven, I. M. J. (2009). Supplemental Calcium Attenuates the Colitis-Related Increase in Diarrhea, Intestinal Permeability, and Extracellular Matrix Breakdown in HLA-B27 Transgenic Rats. J. Nutr. 139: 1525-1533 [Abstract] [Full Text]  
• Vicario, M., Alonso, C., Santos, J. (2009). Impaired intestinal molecular tightness in the mucosa of irritable bowel syndrome: what are the mediators?. Gut 58: 161-162 [Full Text]  
• Arrieta, M C, Madsen, K, Doyle, J, Meddings, J (2009). Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse. Gut 58: 41-48 [Abstract] [Full Text]