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Gut 2006;55:1529a
Copyright © 2006 BMJ Publishing Group Ltd & British Society of Gastroenterology
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Digest

Robin Spiller, Editor, Alastair Watson, Assistant Editor

The first 150 words of the full text of this article appear below.


GASTRIC ACID SUPPRESSION AND THE RISK OF OESOPHAGEAL AND GASTRIC CANCER
It has long been suspected that long term gastric acid suppression might be associated with adenocarcinoma of the oesophagus and stomach. This is the first prospective study examining this question. The study is large, including 4 340 207 patient years follow-up from the British General Practitioner’s research database. Patients given acid suppressing drugs for reflux symptoms had a fivefold increased risk of oesophageal adenocarcinoma, whereas patients treated for gastroduodenal symptoms were not at increased risk. Similarly, patients given acid suppressing drugs for gastric and duodenal ulceration had a fourfold increased risk of gastric non-cardia adenocarcinoma, whereas those treated for oesophageal or other gastroduodenal symptoms were not. Together, these data suggest that the increased risk is derived from the underlying disease and not the acid suppressing drugs themselves.
See p 1538


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