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It has long been suspected that long term gastric acid suppression might be associated with adenocarcinoma of the oesophagus and stomach. This is the first prospective study examining this question. The study is large, including 4 340 207 patient years follow-up from the British General Practitioner’s research database. Patients given acid suppressing drugs for reflux symptoms had a fivefold increased risk of oesophageal adenocarcinoma, whereas patients treated for gastroduodenal symptoms were not at increased risk. Similarly, patients given acid suppressing drugs for gastric and duodenal ulceration had a fourfold increased risk of gastric non-cardia adenocarcinoma, whereas those treated for oesophageal or other gastroduodenal symptoms were not. Together, these data suggest that the increased risk is derived from the underlying disease and not the acid suppressing drugs themselves.
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Associations between long term use of acid suppressing drugs and risk of oesophageal adenocarcinoma (OA) compared with non-users stratified by |
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