COMMENTARY
Oesophageal cancer
Acid inhibitory medication and risk of gastric and oesophageal cancer
Correspondence to:
Correspondence to:
Professor K E L McColl
Section of Medicine, Gardiner Institute, Western Infirmary, 44 Church Street, Glasgow G11 6NT, UK; K.E.L.McColl@clinmed.gla.ac.uk
What are the long term effects of acid suppressive medication on the risk of gastric and oesophageal cancer?
Keywords: histamine H2 antagonists; proton pump inhibitors; gastric acid suppression; oesophageal adenocarcinoma; gastric cancer
| The first 150 words of the full text of this article appear below. |
It is now 30 years since effective antisecretory drugs in the form of H2 receptor antagonists became available for use in clinical practice. Since then the use of medications which elevate intragastric pH has progressively increased and a significant proportion of the population is taking powerful antisecretory medication on a long term basis. In view of the recognised association between hypochlorhydria and gastric cancer,1,2 there has been concern that long term use of acid suppressive medication might increase the risk of this sinister condition. In this issue of Gut, García Rodríguez and colleagues3 report the association between long term antisecretory medication and upper gastrointestinal cancer (see page 1538).
The study used the UK general practitioners research database (GPRD) which is a primary care automated database initiated in the late 1980s and currently including more then 3 million subjects. It contains detailed information on patient demographics,
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Gut 2006 55: 1538-1544.[Abstract] [Full Text] [PDF]
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