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Gut 2006;55:1639
Copyright © 2006 BMJ Publishing Group Ltd & British Society of Gastroenterology.

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More randomised trial evidence on the role of Helicobacter pylori eradication in preventing gastric cancer {blacktriangleright}

{blacktriangleup} You W-C, Brown LM, Zhang L, et al. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst 2006;98:974–83.[Abstract/Free Full Text]

There is persuasive epidemiological evidence implicating Helicobacter pylori as the main cause of non-cardia gastric cancer. There have been randomized controlled trials in China ( Wong BC, et al. JAMA 2004;291:187–94[Abstract/Free Full Text] ) and Colombia (Mera R, et al. Gut 2005;54:1536–40) but these have not had sufficient power to reach definitive conclusions. You et al report a randomised controlled trial of H pylori eradication, vitamin supplementation, and/or garlic in 3365 subjects aged 35–64 years from the Shandong Province in China. Subjects were given a baseline endoscopy and randomised to receive omeprazole 20 mg and amoxicillin 1 g both twice daily for two weeks (in 2258 infected cases), . . . [Full text of this article]


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Relevant Article

Long term follow up of patients treated for Helicobacter pylori infection
R Mera, E T H Fontham, L E Bravo, J C Bravo, M B Piazuelo, M C Camargo, and P Correa
Gut 2005 54: 1536-1540. [Abstract] [Full Text] [PDF]

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