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Histological evaluation of chronic pancreatitis by endoscopic ultrasound-guided fine needle biopsy

¹ Department of Gastroenterology, University Hospital of Santiago de Compostela, Spain, and Foundation for Research in Digestive Diseases (FIENAD), Spain
² Department of Pathology, University Hospital of Santiago de Compostela, Spain
³ Department of Gastroenterology, University Hospital of Santiago de Compostela, Spain, and Foundation for Research in Digestive Diseases (FIENAD), Spain
⁴ Department of Pathology, University Hospital of Santiago de Compostela, Spain
⁵ Department of Gastroenterology, University Hospital of Santiago de Compostela, Spain, and Foundation for Research in Digestive Diseases (FIENAD), Spain

Correspondence to:
Correspondence to:
Dr J Iglesias-García
Department of Gastroenterology, University Hospital of Santiago de Compostela, c/Choupana s/n, 15706 Santiago de Compostela, Spain; jiglesiasg@fienad.com

Keywords: chronic pancreatitis; histological diagnosis; endoscopic ultrasound; fine needle biopsy

The first 150 words of the full text of this article appear below.

Histological diagnosis of chronic pancreatitis has classically been limited to the study of surgical specimens. Histological features of chronic pancreatitis include loss of acinar cells, presence of an irregular interlobular fibrosis, infiltration of inflammatory cells, and relative conservation of intralobular ducts and islets.¹ As pancreatic biopsies are rarely done in the context of chronic pancreatitis, histological characteristics of different stages of the disease are unknown. Endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) has been proved to be a safe and useful method for tissue sampling of intramural and extramural gastrointestinal lesions, including those located in the pancreas.^2,3 Cytological study of material obtained by FNA allows evaluation of cellular findings suggestive of malignancy, but not tissular features of chronic pancreatitis.^4,5 We have recently modified the method of recovering and processing material obtained by EUS guided pancreatic FNA to obtain tissue core specimens for histological evaluation.⁶

The aim of our study . . . [Full text of this article]