LETTER

Does delayed gastric emptying really cause symptoms in functional dyspepsia? We still doubt it!

N J Talley¹, G R Locke, III¹ and J Tack²

¹ Miles and Shirley Fiterman Center for Digestive Diseases, Dyspepsia Center, Mayo Clinic College of Medicine, Rochester, MN, USA
² Department of Gastroenterology, University of Leuven, Belgium

Correspondence to:
Correspondence to:
Dr N J Talley
Mayo Clinic College of Medicine, 200 First Street SW, PL-6-56, Rochester, MN 55905, USA; talley.nicholas@mayo.edu

Keywords: gastric emptying; functional dyspepsia

The first 150 words of the full text of this article appear below.

We enjoyed reading the provocative commentary by Camilleri (Gut 2006;55:909–10) on our large study of patients with functional dyspepsia (Gut 2006;55:933–9). We completely agree that delayed gastric emptying is a marker of disturbed pathophysiology in functional dyspepsia; indeed, we first reported this observation in 1989.¹ However, we remain unconvinced, based on the available data, that this abnormality alone is linked to upper gastrointestinal symptoms.^1–3 Factor analysis studies from the general population, in the absence of objective testing, do not provide insights into this issue,^4,5 although we have shown that non-consulters with dysmotility-like dyspepsia are more likely to have gastric emptying delay.⁶ Studies from selected tertiary care patients are of interest, but Camilleri has previously reported negative results.³ Importantly, in a previous study of 551 patients with functional dyspepsia and 247 patients with type I diabetes and postprandial dyspepsia, gastric emptying, as measured . . . [Full text of this article]

M Camilleri

Correspondence to:
Correspondence to:
Dr M Camilleri
Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Group, Mayo Clinic College of Medicine, Charlton 8-110, 200 First St SW, Rochester, MN 55905, USA; camilleri.michael@mayo.edu

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