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Preliminary data on the use of intraductal optical coherence tomography during ERCP for investigating main pancreatic duct strictures

Division of Gastroenterology and Gastrointestinal Endoscopy, University Vita-Salute San Raffaele, Scientific Institute San Raffaele, Milan, Italy

Correspondence to:
Correspondence to:
Dr P Alberto Testoni
Division of Gastroenterology and Gastrointestinal Endoscopy, University Vita-Salute San Raffaele, Scientific Institute San Raffaele, Via Olgettina 60, 20132, Milan, Italy; testoni.pieralberto@hsr.it

Keywords: optical coherence tomography; main pancreatic duct strictures; endoscopic retrograde cholangiopancreatography; ERCP

The first 150 words of the full text of this article appear below.

Optical coherence tomography (OCT) is an optical imaging technique that uses infrared light reflectance and produces high resolution microstructural cross sectional images of tissues in vivo.^1–3 The OCT probe can be inserted inside a standard transparent endoscopic retrograde cholangiopancreatography (ERCP) catheter. To date, only the epithelium of the main pancreatic duct (MPD) has been examined by OCT in humans in three studies: one post mortem⁴ and two ex vivo.^5,6 The aim of the present prospective pilot study was to assess the feasibility of intraductal OCT in vivo during an ERCP procedure, its ability to identify changes in MPD wall structure in vivo, and its ability to differentiate non-neoplastic from neoplastic tissue in the presence of MPD strictures.

Fifteen consecutive patients with documented or suspected MPD strictures at a previous computed tomography scan or magnetic resonance cholangio-pancreatography (MRCP) were investigated by endoscopic ultrasonography (EUS) and ERCP; the two procedures were done . . . [Full text of this article]