EDITORIAL
Inflammatory bowel disease
Probiotics, prebiotics, synbiotics: ecological treatment for inflammatory bowel disease?
Correspondence to:
Correspondence to:
P Marteau
Service D’ Hepato-Gastroenterologie Hopital, Lariboisiere 2 rue A. Paré, Paris 75010, France;philippe.marteau@egp.ap-hop-paris.fr
Ecological treatment may be beneficial in patients with ulcerative colitis
| The first 150 words of the full text of this article appear below. |
A clinical study published previously in Gut suggests for the first time that an ecological treatment combining a prebiotic mixture of fructo-oligosaccharides (FOS) of different chain length with a Bifidobacterium longum (a synbiotic) could have therapeutic benefits in the distal colon of patients with acute ulcerative colitis.1
In this randomised double-blind pilot trial, a marked decrease in endoscopic lesions in the distal colon was observed in the ecological treatment group but not in the placebo group. The biological markers of inflammation in the mucosa, tumour necrosis factor 
, interleukin (IL) 1- and the human ß-defensins 2, 3 and 4, decreased (ie, were ameliorated) in the group receiving the ecological treatment. This study will probably not convince most clinicians because of the low number of subjects, the use of concomittent treatments and the lack of histological inflammation score. However, pilot studies such as this one will hopefully bridge
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