COMMENTARY
Aeitopathogenesis of IBS
Genes and environment in irritable bowel syndrome: one step forward
Correspondence to:
Correspondence to:
Professor N J Talley
Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic College of Medicine, 200 First Street SW, PL-6-56, Rochester, MN 55905, USA; talley.nicholas@mayo.edu
Both low birth weight and genetic factors may be integral to the aetiological pathway in irritable bowel syndrome
| The first 150 words of the full text of this article appear below. |
The prototypic functional gastrointestinal disorder is irritable bowel syndrome (IBS) which affects approximately 10% of the population and causes considerable morbidity.1 Traditionally, the pathogenesis of IBS has been simplistically conceptualised by applying the biopsychosocial model; this focuses on the interaction, via the brain–gut axis, of psychosocial processes with pertubations of gut sensory and motor dysfunction.2 The model suggests that either genetic or environmental factors may alter central and peripheral physiology. However, how this occurs remains mysterious, few environmental factors have been linked to IBS and indeed whether or not genetics plays a part remains controversial.
There are clues that IBS is an inherited condition.3–5 In a family cluster study of 643 subjects from Olmsted County, Minnesota, those who reported having first degree relatives with bowel problems were significantly more likely to report IBS, adjusting for age, sex and the reporting of non-gastrointestinal somatic symptoms.3 Those who reported
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