Recent advances in clinical practice

Influence of obesity on the risk of developing colon cancer

E E Frezza, M S Wachtel, M Chiriva-Internati

Texas Tech University Health Sciences Center, Texas, USA

Correspondence to:
Dr E E Frezza
Department of Surgery, Division of General Surgery, Texas Tech University Health Sciences Center, MOP Building, Suite 380, 3502 9th St, Lubbock, Texas 79415, USA; eldo.frezza@ttuhsc.edu

Keywords: obesity; colon cancer; insulin; leptin; visceral abdominal fat

The first 150 words of the full text of this article appear below.

Obesity is a risk factor for many diseases. Thirty per cent of Americans are viewed as super obese; therefore, we need to find a solution. We already know about the diseases associated with obesity such as high blood pressure, diabetes, sleep apnoea, etc. Lately, there has been an increased interest in understanding if cancer is related to obesity. In this paper, we review the incidence of colon cancer and obesity.

Insulin is the best established biochemical mediator between obesity and colon cancer. Hyperinsulinaemia, such as occurs in type II diabetes, is important in the pathogenesis of colon cancer. All adipose tissue is not equal. Visceral abdominal fat has been identified as the essential fat depot for pathogenetic theories that relate obesity and colon cancer. The genders differ as regards to how the relationship between obesity and colon cancer has been evaluated. Obesity imposes a greater risk of colon cancer for . . . [Full text of this article]

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Chronic sub-clinical bowel inflammation may explain increased risk of colorectal cancer in the obese

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