COMMENTARY
Crohn's disease
To feed or not to feed? Are nutritional supplements worthwhile in active Crohn’s disease?
Correspondence to:
Correspondence to:
Dr H Lochs
Medizinische Klinik mit Schwerpunkt Gastroenterologie, Hepatologie und Endokrinologie, Charité Universitätsmedizin Berlin, Schumannstr 20/21, D 10117 Berlin, Germany; herbert.lochs@charite.de
Partial enteral nutrition is unlikely to suppress inflammation and so treat active Crohn’s disease
Keywords: Crohn’s disease; enteral nutrition; elemental diet; children
| The first 150 words of the full text of this article appear below. |
Enteral nutrition is an effective therapy for active Crohn’s disease (CD) although less effective than steroids. This has been shown in a number of original studies and meta-analyses.1,2 Enteral nutrition leads to remission in approximately 60% of patients within 4–6 weeks. Unfortunately, enteral nutrition has never been compared with placebo or other medical therapies such as mesalamine or topical steroids. With the lack of such studies demonstrating that enteral nutrition is superior to placebo, the question has been raised if enteral nutrition has any therapeutic effect at all. However, remission rates with enteral nutrition range from 53% to 80%, which is higher than remission rates of placebo groups in most studies, which range from 18% to 40%. Therefore, a direct anti-inflammatory effect of enteral nutrition in active CD is generally accepted. The therapeutic efficacy of enteral nutrition in active CD is also suggested by results of recent studies
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Gut 2006 55: 356-361.[Abstract] [Full Text] [PDF]
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