Digest
| The first 150 words of the full text of this article appear below. |
It is know that short peptides from
-gliaden stimulate T cells in coeliac disease. The binding of these peptides to human leukocyte antigens (DQ2 and DQ8) is greatly enhanced when the peptides are deamidated by tissue transglutaminase. It has been hypothesised that the deamidation of a few specific gliadin peptides is responsible for the chronic inflammation of coeliac disease. However, this hypothesis has not been tested directly. Data are presented that tissue transglutaminase can deamidate a wide range of gliadin peptides. Furthermore, deamidation causes the binding and long term immobilisation of gliadin peptides to collagen, which contributes the chronicity of inflammation. This binding is also associated with increased titres of anticollagen antibodies, which may explain the high incidence of autoimmune disease in coeliac patients.
See p 478
|
Many inflammatory illnesses are associated with anorexia but the mechanisms involved are uncertain. The
Relevant Articles
- Cross linking to tissue transglutaminase and collagen favours gliadin toxicity in coeliac disease
- W Dieterich, B Esslinger, D Trapp, E Hahn, T Huff, W Seilmeier, H Wieser, and D Schuppan
Gut 2006 55: 478-484.[Abstract] [Full Text] [PDF]
- Vanilloids in pancreatic cancer: potential for chemotherapy and pain management
- M Hartel, F F di Mola, F Selvaggi, G Mascetta, M N Wente, K Felix, N A Giese, U Hinz, P Di Sebastiano, M W Büchler, and H Friess
Gut 2006 55: 519-528.[Abstract] [Full Text] [PDF]
- Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial
- T N Brooklyn, M G S Dunnill, A Shetty, J J Bowden, J D L Williams, C E M Griffiths, A Forbes, R Greenwood, and C S Probert
Gut 2006 55: 505-509.[Abstract] [Full Text] [PDF]
- In vivo imaging of cerebral "peripheral benzodiazepine binding sites" in patients with hepatic encephalopathy
- A Cagnin, S D Taylor-Robinson, D M Forton, and R B Banati
Gut 2006 55: 547-553.[Abstract] [Full Text] [PDF]
- Four year follow up of fatigue in a geographically defined primary biliary cirrhosis patient cohort
- D E J Jones, N Bhala, J Burt, J Goldblatt, M Prince, and J L Newton
Gut 2006 55: 536-541.[Abstract] [Full Text] [PDF]
- Immune control of food intake: enteroendocrine cells are regulated by CD4+ T lymphocytes during small intestinal inflammation
- J R McDermott, F C Leslie, M DAmato, D G Thompson, R K Grencis, and J T McLaughlin
Gut 2006 55: 492-497.[Abstract] [Full Text] [PDF]
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
