Gut

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER


[Advanced]
Correction for Travis et al., Gut 55 (Supplement 1) i16-i35.
Gut 2006;55:437
Copyright © 2006 BMJ Publishing Group Ltd & British Society of Gastroenterology
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Spiller, R.
Right arrow Articles by Watson, A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Spiller, R.
Right arrow Articles by Watson, A.
Topic Collections
Right arrowRelevant Articles

Digest

Robin Spiller, Alastair Watson, Editor and Deputy Editor

The first 150 words of the full text of this article appear below.


CROSS LINKING OF GLIADIN BY TISSUE TRANSGLUTAMINASE IS A CRITICAL PART OF THE PATHOGENESIS OF COELIAC DISASE
It is know that short peptides from {alpha}-gliaden stimulate T cells in coeliac disease. The binding of these peptides to human leukocyte antigens (DQ2 and DQ8) is greatly enhanced when the peptides are deamidated by tissue transglutaminase. It has been hypothesised that the deamidation of a few specific gliadin peptides is responsible for the chronic inflammation of coeliac disease. However, this hypothesis has not been tested directly. Data are presented that tissue transglutaminase can deamidate a wide range of gliadin peptides. Furthermore, deamidation causes the binding and long term immobilisation of gliadin peptides to collagen, which contributes the chronicity of inflammation. This binding is also associated with increased titres of anticollagen antibodies, which may explain the high incidence of autoimmune disease in coeliac patients.
See p 478


Figure 1
Tissue transglutaminase expression in the wall of the oesophagus.


HOW JEJUNAL INFLAMMATION INDUCES ANOREXIA: ROLE OF CCK AND 5-HT
Many inflammatory illnesses are associated with anorexia but the mechanisms involved are uncertain. The . . . [Full text of this article]


Relevant Articles

Cross linking to tissue transglutaminase and collagen favours gliadin toxicity in coeliac disease
W Dieterich, B Esslinger, D Trapp, E Hahn, T Huff, W Seilmeier, H Wieser, and D Schuppan
Gut 2006 55: 478-484. [Abstract] [Full Text] [PDF]

Vanilloids in pancreatic cancer: potential for chemotherapy and pain management
M Hartel, F F di Mola, F Selvaggi, G Mascetta, M N Wente, K Felix, N A Giese, U Hinz, P Di Sebastiano, M W Büchler, and H Friess
Gut 2006 55: 519-528. [Abstract] [Full Text] [PDF]

Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial
T N Brooklyn, M G S Dunnill, A Shetty, J J Bowden, J D L Williams, C E M Griffiths, A Forbes, R Greenwood, and C S Probert
Gut 2006 55: 505-509. [Abstract] [Full Text] [PDF]

In vivo imaging of cerebral "peripheral benzodiazepine binding sites" in patients with hepatic encephalopathy
A Cagnin, S D Taylor-Robinson, D M Forton, and R B Banati
Gut 2006 55: 547-553. [Abstract] [Full Text] [PDF]

Four year follow up of fatigue in a geographically defined primary biliary cirrhosis patient cohort
D E J Jones, N Bhala, J Burt, J Goldblatt, M Prince, and J L Newton
Gut 2006 55: 536-541. [Abstract] [Full Text] [PDF]

Immune control of food intake: enteroendocrine cells are regulated by CD4+ T lymphocytes during small intestinal inflammation
J R McDermott, F C Leslie, M D’Amato, D G Thompson, R K Grencis, and J T McLaughlin
Gut 2006 55: 492-497. [Abstract] [Full Text] [PDF]





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 2006 BMJ Publishing Group Ltd & British Society of Gastroenterology