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Designing Spiegelmers to antagonise ghrelin

Correspondence to:
Correspondence to:
Dr P J Hornby
Enterology Biology Team Leader, Johnson & Johnson, Research and Development L L C, UK; phornby@prdus.jnj.com

Keywords: ghrelin; obesity; antagonism; NOX-B11; food intake; rat

The first 150 words of the full text of this article appear below.

The article by Kobelt and colleagues¹ in this issue of Gut, further explores a novel mechanism to interfere with the action of ghrelin on its receptor, growth hormone secretagogue receptor 1 (GHS-R) (see page 788). Ghrelin is a 28 amino acid peptide localised immunocytochemically in parietal cells of the human stomach² where it is released and stimulates growth hormone release, food intake, and adiposity. Human plasma has relatively low levels of ghrelin³ although, somewhat counter intuitively, in anorectic patients the fasting level of ghrelin, including the active form (n-octanoyl modification at serine 3), is significantly higher.⁴ The main impact of this work is that the investigators have demonstrated the efficacy of and dose related inhibition of ghrelin stimulated food intake in rats. They did this by using a biological approach to bind to ghrelin and prevent the interaction of ghrelin with its receptor in . . . [Full text of this article]

Related Article

Anti-ghrelin Spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats

P Kobelt, S Helmling, A Stengel, B Wlotzka, V Andresen, B F Klapp, B Wiedenmann, S Klussmann, and H Mönnikes
Gut 2006 55: 788-792. [Abstract] [Full Text] [PDF]