LETTER

DLG5 variants and susceptibility to inflammatory bowel disease in the Scottish population

B L Browning

Correspondence to:
Correspondence to:
Dr B L Browning
Nutrigenomics Program, University of Auckland, Private Bag 92019, Auckland 1001, New Zealand; b.browning@auckland.ac.nz

Keywords: DLG5 variants; inflammatory bowel disease; Scottish population

The first 150 words of the full text of this article appear below.

The recent study by Noble et al (Gut 2005;54:1416–20) did not find an association of the DLG5 G113A polymorphism with either inflammatory bowel disease (IBD) or Crohn’s disease (CD). Previous studies in other European populations had reported an increase in 113A allele frequency in IBD and CD patients^1,2 but, in striking contrast, Noble et al reported a trend towards decreased carrier frequency for the 113A allele in IBD (p = 0.069) and CD (p = 0.057) patients. We believe there is reason to re-examine the genotype data used in the report of Noble et al.

Firstly, there was a significant difference in the proportion of missing genotypes between the IBD patients and controls (p<0.00001, Fisher’s exact test). Using the data in tables 1 and 3, the missing genotype rate was 13% in controls and 4% in IBD patients. This difference strongly suggests differences in DNA . . . [Full text of this article]

J Satsangi, C Noble, I D R Arnott, R K Russell, E R Nimmo

Gastrointestinal Unit, Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Edinburgh, UK

Correspondence to:
Correspondence to:
Professor J Satsangi
Gastrointestinal Unit, Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK; j.satsangi@ed.ac.uk

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Relevant Article

DLG5 variants do not influence susceptibility to inflammatory bowel disease in the Scottish population

C L Noble, E R Nimmo, H Drummond, L Smith, I D R Arnott, and J Satsangi
Gut 2005 54: 1416-1420. [Abstract] [Full Text] [PDF]