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Gut 2006;55:909-910; doi:10.1136/gut.2005.086355
Copyright © 2006 BMJ Publishing Group Ltd & British Society of Gastroenterology.

COMMENTARIES

Dyspepsia

Does delayed gastric emptying really cause symptoms in functional dyspepsia?

M Camilleri

Correspondence to:
Correspondence to:
Professor M Camilleri
Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA; camilleri.michael@mayo.edu


When the glove does fit, you should not acquit

Keywords: functional dyspepsia; gastric emptying; quality of life; early satiety

The first 150 words of the full text of this article appear below.

In this month’s issue of Gut, Talley and colleagues1 report an interesting study on the opportunistic use of a database, acquired during the baseline period of four multicentre therapeutic trials, to explore the associations between gastric emptying and symptoms in functional dyspepsia (see page 933). This was not a prospective study designed to specifically address the question posed in the title of this commentary. Before analysing the information from this study, it is opportune to review three concepts that reflect recent papers from the literature.

Firstly, combinations of symptoms are associated with abnormal gastric functions. In a scholarly review, Tack et al surmised that 40–50% of patients with dyspepsia had impaired gastric accommodation after meal ingestion, 34–66% had gastric hypersensitivity, and 23–59% had delayed gastric emptying.2 Moreover, delayed gastric emptying was associated with early satiety, nausea, vomiting and fullness; impaired gastric accommodation with early satiety . . . [Full text of this article]


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Does delayed gastric emptying really cause symptoms in functional dyspepsia? We still doubt it! Author’s reply
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