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Fertility and pregnancy in the patient with inflammatory bowel disease

Correspondence to:
Correspondence to:
Dr U Mahadevan
Department of Medicine, University of California San Francisco, Center for Colitis and CD, 2330 Post Street #610, San Francisco, CA 94115 USA; uma.mahadevan@ucsf.edu

Keywords: inflammatory bowel disease; Crohn’s disease; ulcerative colitis; pregnancy; fertility

The first 150 words of the full text of this article appear below.

The majority of patients with inflammatory bowel disease (IBD) are affected during their peak reproductive years.¹ While initial concerns focus on attaining a durable remission and avoiding the side effects of medications, once in remission the focus often shifts to the effect of disease and the medications used to treat it on fertility and the ability to conceive a healthy child. This paper summarises the existing literature on the effects of ulcerative colitis (UC) and Crohn’s disease (CD) and the medications used to treat it on fertility and pregnancy outcomes.

GENETICS AND INHERITANCE
Patients are naturally concerned about passing their disease on to their offspring. Unfortunately, family history is the strongest predictor for developing IBD. If one parent is affected, the risks of the offspring developing IBD are 2–13 times higher than in the general population.^2,3 One study estimated that the risks of IBD in first degree relatives of probands with UC and . . . [Full text of this article]