LETTER

Reduced microbial diversity in inflammatory bowel diseases

S J Ott, S Schreiber

Institute for Clinical Molecular Biology, UKSH Campus Kiel, Germany

Correspondence to:
Correspondence to:
Professor S Schreiber
Institute for Clinical Molecular Biology, Christian-Albrechts-University Kiel, Schittenhelmstr. 12, 24105 Kiel, Germany; s.schreiber@mucosa.de

Keywords: microbial diversity; inflammatory bowel diseases

The first 150 words of the full text of this article appear below.

Intestinal microbiota have become the subject of intense investigation in inflammatory bowel disease (IBD) over the past years after some groups demonstrated that significant alterations of the composition of enteric bacteria might be related to the underlying inflammatory process (Gut 2006;55:205–11).^1–4 However, the complexity of the intestinal microbiota and the availability of a variety of different experimental approaches generated sometimes conflicting and inconsistent data. Manichanh et al (Gut 2006;55:205–11) recently published an extensive study using metagenomic libraries, a novel molecular technique allowing the recruitment of full molecular information of complex microbial habitats. In metagenomic clone libraries with more than 25 000 clones that were generated from faecal samples of healthy subjects and active Crohn’s patients, significant loss of indigenous bacteria was found.

The article confirms our report that reduced bacterial diversity seems to be a hallmark of the biofilm in IBD.⁴ Using colonic . . . [Full text of this article]

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Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach

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